Antidiabetic Properties Of Andrographis Paniculata Nees And Eugenia Polyantha Wight Leaves In Wistar Rats By Oral Glucose Tolerance Test

Widharna, Ratna Megawati and Ferawati, . and Hendriati, Lucia and Surjadhana, Adrianta and Jonosewojo, Arijanto and Widjajakusuma, Elisabeth Catherina (2010) Antidiabetic Properties Of Andrographis Paniculata Nees And Eugenia Polyantha Wight Leaves In Wistar Rats By Oral Glucose Tolerance Test. In: Proceeding International Conference And Talk Show On Medicinal Plant Effective, Safe And Qualified Herbal Medicine For Diabetes Mellitus Treatment, 9th – 21st October 2010, Jakarta.

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Abstract

Ethanol and water extract of Andrographis paniculata Nees, and ethanol extract of Eugenia polyantha Wight leaves were evaluated for their hypoglycemic effects in healthy albino Wistar rats by oral glucose tolerance test. Both ethanol extract of Euginia polyantha (200 mg/kg bw) and water extract of Andrographis paniculata (200 mg/kg bw) showed significant increase of blood glucose level at T30 and T60 (T30 = 30 minutes after glucose loading or 60 minutes after drugs administration, T60 = 60 minutes after glucose loading or 90 minutes after drugs administration). Meanwhile, ethanol extract of Andrographis paniculata (200 mg/kg bw) showed significant increased in blood glucose level up to T90. Therefore, water extract of Andrographis paniculata (200 mg/kg bb) was considered faster to lower blood glucose level than the ethanol extract at the same dose of administration. Furthermore, water extract of Andrographis paniculata and Euginia polyantha leaves could be selected for further research as they reduce the blood glucose level steadily and does not cause hypoglycemia such as in glibenclamide.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Andrographis paniculata Nees extract, Eugenia polyantha Wight leaves extract, oral glucose tolerance test
Subjects: Pharmacy
Divisions: Proceeding > Faculty of Pharmacy
Depositing User: Vincentius Widya Iswara
Date Deposited: 22 Jan 2015 07:04
Last Modified: 19 Jul 2016 02:46
URI: http://repository.wima.ac.id/id/eprint/1099

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