Preparation of antibacterial bentonite - β lactam antibiotic composite

Hanelin, Gisela Anke and Wiyanto, Lukius Denny (2017) Preparation of antibacterial bentonite - β lactam antibiotic composite. Working Paper (Laporan Penelitian Laboratorium). Faculty of Engineering, Surabaya. (Unpublished)

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Abstract

Antibiotic potential for people who are injured get infection are high. First aid to evade the infection use antibiotics. Antibiotics have ability to inhibit or kill bacteria that cause infection. Tetracycline is antibiotic that usually uses for first treatment because of tetracycline easy to obtain. There are six classification of carbapenem antibiotic such as imipenem, ertapenem, mesopenem, and doripenem. Doripenem is one of the classification of carbapenem that can be obtained easily. Doripenem can be used for first aid if infection is happened. Silver usually uses too for avoiding infection but it is not easily to degrade. It is necessary to find antibacterial composites that easily to find and biodegradable. The purpose of this research is to study the effect of pH, kinetic, and isotherm adsorption of doripenem into bentonite. The optimum condition of doripenem adsorption will be determined. After knowing the optimum condition, the antibacterial composite will be tested on nutrient agar. This research has been done in 5 steps, purification of bentonite before it is used for adsorption using H2O2, tested the effect of pH doripenem on adsoption has been done and from the results show that the optimum pH to adsorp doripenem onto bentonite is at pH 3 (26.8035 mg/g), adsorption kinetics using bentonite as adsorbents fitted better with pseudo – first order model (R2=0.9935) and it takes 48h until the doripenem cannot be adsorped onto bentonite surface. This mean doripenem loading into bentonite dominated by physiosorption, Isotherm adsorption of doripenem into bentonite and antibacterial composite that tested in nutrient agar makes wider area if the doripenem concentration is higher.

Item Type: Monograph (Working Paper (Laporan Penelitian Laboratorium))
Uncontrolled Keywords: Adsorption, bentonite, doripenem
Subjects: Engineering
Engineering > Chemical Engineering
Divisions: Faculty of Engineering > Chemical Engineering Study Program
Depositing User: Users 4801 not found.
Date Deposited: 25 Jan 2018 14:06
Last Modified: 25 Jan 2018 14:06
URI: http://repository.wima.ac.id/id/eprint/13213

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