Effect of Andrographis Paniculata to the Expression of IL-6, IL-17, IL-10, TGFβ, and the Ratio of Treg/ Th17 in Sprague Dawley Rats with Atherosclerosis Diet an dCigarette Smoke

Novita,, Bernadette Dian and Theodora, Imelda and Tamayanti, Wahyu Dewi and Pramono, Adi (2016) Effect of Andrographis Paniculata to the Expression of IL-6, IL-17, IL-10, TGFβ, and the Ratio of Treg/ Th17 in Sprague Dawley Rats with Atherosclerosis Diet an dCigarette Smoke. International Journal of Science and Research (IJSR), 5 (2). pp. 100-107. ISSN 2319-7064

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Official URL: https://www.ijsr.net/archive/v5i2/NOV161038.pdf

Abstract

Abstract: Atherosclerosis is a chronic, active and progressiveinflammatorydisease of the arterial wall controlled by native and adaptive immune responses (René,et al 2010). Continuous exposure of oxidizedLDL causesmacrophages activated more and produces pro-inflammatory cytokines and proteases. The pro-inflammatory cytokines lead to thedifferentiation of naiveT cells tend to become pro-inflammatoryeffectorT cells such as Th1, Th2 and Th17 (T helper) than to counter-inflammatoryTregulator cells. The aim of this studywas to determinetherole of the ethanol extract of Andrographispaniculata in slowingtheinflammatoryreaction by increasing theratio of Treg/ Th17 cells and increasingthe amount of expression of counter-inflammatory cytokines (IL-10 and TGF β) than pro- inflammatory cytokines (IL-6 and IL-17) in Sprague DawleyratswithAtherosclerosisDiet and Smoke induction.Thisstudy uses a posttest experimental designcontrolstudy. Samples taken at random. The research was conducted in vivo to demonstratethe effect of ethanol extract of Andrographispaniculata in a variety of dosage on theexpression of IL-6, IL-17, IL-10, TGF-β and theratio of Treg/ Th17 cells, in Sprague DawleyratswithAtherosclerosisDiet andSmoke induction. Theresultsshowed that ethanol extract of Andrographispaniculata at a dose of 1.2 mg / kg in Sprague DawleyratswithAtherosclerosis Diet and Smoke induction, take effect on IL-17, and the ratio of Treg/Th17 cells (p <0.05). Expression of IL-17 was significantly higher in the group of ethanol extract of Andrographispaniculata at a dose of 1.2 mg / kg compared to the negative control. Based on the above data, it can be concluded thatthe ethanol extract of Andrographis paniculata can reduce chronic inflammation and therisk of atherosclerosis in the blood vessels of Sprague Dawleyrats with Atherosclerosis Diet andSmoke induction Keywords: Andrographispaniculata

Item Type: Article
Uncontrolled Keywords: Andrographispaniculata,atherosclerosis,inflammation, Treg, Th17, IL-10, TGF-β, IL-6, IL-17
Subjects: Medicine > R Medicine (General)
Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Depositing User: Dr Bernadette Dian Novita Dewi
Date Deposited: 27 Sep 2018 07:33
Last Modified: 22 Feb 2019 01:17
URI: http://repository.wima.ac.id/id/eprint/14434

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