Metformin Associated Inflammation Levels Regulation in Type 2 Diabetes Mellitus-Tuberculosis Coinfection Patients – A Case Report

Novita, Bernadette Dian and Soediono, Endang Isbandiati (2018) Metformin Associated Inflammation Levels Regulation in Type 2 Diabetes Mellitus-Tuberculosis Coinfection Patients – A Case Report. Indian Journal of Tuberculosis, 65 (4). pp. 345-349. ISSN 0019-5707

[img]
Preview
Text
Met associated Tcell.pdf

Download (684kB) | Preview
[img]
Preview
Text (METFORMIN ASSOCIATED INFLAMMATION LEVELS REGULATION IN TYPE 2 DIABETES MELLITUS-TUBERCULOSIS COINFECTION PATIENTS – A CASE REPORT.)
1-Metformin_associated_inflammation_.pdf

Download (772kB) | Preview
[img]
Preview
Text (METFORMIN ASSOCIATED INFLAMMATION LEVELS REGULATION IN TYPE 2 DIABETES MELLITUS-TUBERCULOSIS COINFECTION PATIENTS – A CASE REPORT.)
1-Metformin_associated_.pdf

Download (389kB) | Preview
[img]
Preview
Text (METFORMIN ASSOCIATED INFLAMMATION LEVELS REGULATION IN TYPE 2 DIABETES MELLITUS-TUBERCULOSIS COINFECTION PATIENTS – A CASE REPORT_peer_review)
1-R1&2-Metformin_associated_.pdf

Download (255kB) | Preview
[img]
Preview
Text (METFORMIN ASSOCIATED INFLAMMATION LEVELS REGULATION IN TYPE 2 DIABETES MELLITUS-TUBERCULOSIS COINFECTION PATIENTS – A CASE REPORT.)
1-Metformin_associated_Hasil Cek Similarity.pdf

Download (2MB) | Preview
Official URL: https://authors.elsevier.com/tracking/article/deta...

Abstract

IFN-γ elevation is one of the indicators of successful treatment in active tuberculosis (TB) infection due to macrophage and Th-1 activation in inducing autophagy process. However, IL-10 also inhibits interferon-mediated mycobactericid activities by blocking IFN-γ signaling pathways in autophagy. Therefore, ratio IFN-γ / IL-10 has to be greater than 1 (>1) then IFN-γ remains has anti-mycobacterium. Metformin (MET) is a potent combination drug to elevate anti-TB efficacy and able to regulate inflammation. In this study, an observational clinical study was done in diabetes mellitus (DM)-TB co-infection outpatients at Surabaya Paru Hospital. This study evaluated how MET therapy affected inflammation. MET was used at least 2 months, accompanying with insulin and anti-TB and as comparison to non MET group. The result in this study MET increased both pro-inflammatory and anti-inflammatory cytokines, thus MET may consider as adjunct therapy in DM-TB coinfection patients due to its ability in Th-1 and Th-2 immuno-regulating response, especially to enhance IFN-γ and to reduce insulin associated IL-10 upregulation. Keywords: type 2 diabetes mellitus-tuberculosis co-infection; metformin; ratio interferon gamma and interleukin-10

Item Type: Article
Additional Information: Jurnal Ilmiah Internasional Q4, H-Indexs 16
Uncontrolled Keywords: type 2 diabetes mellitus-tuberculosis co-infection; metformin; ratio interferon gamma and interleukin-10
Subjects: Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Depositing User: Dr Bernadette Dian Novita Dewi
Date Deposited: 06 Sep 2018 04:13
Last Modified: 22 Feb 2019 01:07
URI: http://repository.wima.ac.id/id/eprint/16233

Actions (login required)

View Item View Item