In Vitro 5-LOX Inhibitory and Antioxidant Activities of Extracts and Compounds from the Aerial Parts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm

Wijaya, Sumi and Jin, Khoo Teng and Nee, Ting Kang and Wiart, Christophe (2012) In Vitro 5-LOX Inhibitory and Antioxidant Activities of Extracts and Compounds from the Aerial Parts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. Journal of Complementary and Integrative Medicine, 9 (1). pp. 1-14. ISSN 1553-3840, Journal Internasional Bereputasi Q2, SJR 0.206

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Official URL: https://www.degruyter.com/view/j/jcim.2012.9.issue...

Abstract

The aim of this study was to investigate the antioxidant and anti-inflammatory potentials of crude extracts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. and its isolated compounds. Separation and structure elucidation of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. were conducted using chromatographic and spectroscopic method. The antioxidant activities of the extracts in this study were determined by the ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-carotene bleaching assays meanwhile the antiinflammatory activity was evaluated using the 5-lipoxygenase assay. Seven known compounds quercetin 3-O-glucoside (1), naringenin 7-O-glucoside (2), seneciphylline-O-glucoside (3), chrysoeriol (4), retrorsine (5), adonifiline (6) and 5,4′-di-O-methyl alpinumisoflavone (7) were isolated from ethanol extract of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. The ethanol and water extracts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. elicited potent antioxidant and anti-inflammatory properties. Amongst the isolated compounds quercetin 3-Oglucoside gave strong antioxidant activity and adonifiline strongly inhibited 5-lipoxygenase activity.

Item Type: Article
Additional Information: Journal Internasional Bereputasi, Q2, SJR 0.294
Uncontrolled Keywords: Lopholaena coriifolia, flavonoids, alkaloids, antioxidant, anti-inflammatory
Subjects: Pharmacy
Divisions: Journal Publication
Depositing User: F.X. Hadi
Date Deposited: 09 Oct 2019 08:00
Last Modified: 01 Oct 2020 02:30
URI: http://repository.wima.ac.id/id/eprint/20126

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