Neuroprotective Activity of Emila sonchifolia (L.) DC. (Asteraceae Bercht. & J. Presl)

Wijaya, Sumi and Ting, Kang-Nee and Khoo, Teng-Jin and Wiart, Christophe (2011) Neuroprotective Activity of Emila sonchifolia (L.) DC. (Asteraceae Bercht. & J. Presl). In: Proceeding The International Symposium on Medicinal and Aromatic Plants, 15-18 Dec. 2011, Chiang Mai, Thailand, ISBN: 978-602-95911-1-8.

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Abstract

A phytochemical study on the ethanol extract of tassel flower (Emilia sonchifolia) led to the isolation of senecionine-N-oxide (1), kaempferol 3-O-rutinoside (2) and protocatechuic acid (3). The structures of these compounds were determined using spectroscopic analyses (UV, NMR and MS), with comparison of their spectral data with previously reported values. These compounds were reported for the first time for this plant. Neuroprotective properties of the ethanol extract and the isolated compounds were examined using antioxidant, cytoprotective, anti-inflammatory and acetylcholin-esterase inhibitory assays. Antioxidant activity was evaluated using ferric reducing antioxidant power (FRAP), β-carotene bleaching and 2, 2-diphenyl- 1-picrylhydrazyl (DPPH) assays. Compounds 2 and 3 displayed profound antioxidant capacities. Compound 2 elicited high cytoprotection with the percentage of protection 56.62% and significant inhibition of 5-lipoxygenase (5-LOX) activities with IC50 44.59 μg ml-1. Compound 2 is also acetylcholinesterase inhibitor.

Item Type: Conference or Workshop Item (Paper)
Additional Information: ISBN:978-602-95911-1-8
Uncontrolled Keywords: antioxidant, cytoprotective, anti-inflammatory, acetylcholinesterase inhibitor
Subjects: Pharmacy
Divisions: Proceeding
Depositing User: F.X. Hadi
Date Deposited: 27 Nov 2019 03:22
Last Modified: 01 Oct 2020 04:39
URI: http://repository.wima.ac.id/id/eprint/20194

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