The Lipid Lowering Effect of Water Extract of Andrographis paniculata, Water Extract of Syzigium polyanthum and its Combination in Alloxan-Induced Diabetic Rats

Wijaya, Sumi and Darsono, Farida L. (2014) The Lipid Lowering Effect of Water Extract of Andrographis paniculata, Water Extract of Syzigium polyanthum and its Combination in Alloxan-Induced Diabetic Rats. In: Proceeding Surabaya 1st International Symposium of Traditional Complementary and Alternative Medicine., 12-13 April 2014, Fakultas Farmasi UNAIR, ISSN: 2355-598X.

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Abstract

Combination of water extract of Andrographis paniculata and water extract of Syzygium polyanthum (6:1) have been reported to reduce blood glucose in normal and alloxan rats. This combination also gave protection effects on kidney, liver and pancreas animals tested from alloxan toxicity Methods : Eighty male white albino rats were divided into eight different groups including normal control, diabetic control, 4 treated groups with the water extract of Andrographis paniculata, water extract of Syzygium polyanthum and its combination, and also standard drugs (metformin, insulin) with 10 rats in each group. The extracts and the standard were given orally for 7 days. At day 7 blood sample was collecte'd, serum separated and glycemic level, total cholesterol, LDL, HDL, triglyceride, and alkaline phosphatase were determined. The body weight was recorded on day 1 and day 7. Results and discussion: The data obtained revealed that the water extract of Andrographis paniculata (WAP), water extract of Syzygium polyanthum (WSP) and its combination (1 WAP: 6 WSP; 6 WAP:1 WSP) reduced the glucose level. The treatment with these extracts also reduced the LDL and triglyceride level significantly and alkaline phospatase level as compared with normal and diabetic groups. Conclusions: The water extract of Andrographis paniculata, water extract of Syzygium polyanthum and its combination possess significant antidiabetic activity along with antihypercholesterolemic activity. Key words: Andrographis paniculata, Syzygium polyanthum, water extracts, antidiabetic, antihypercholesterolemic

Item Type: Conference or Workshop Item (Paper)
Additional Information: ISSN: 2355-598X
Uncontrolled Keywords: Andrographis paniculata, Syzygium polyanthum, water extracts, antidiabetic,antihypercholesterolemic
Subjects: Pharmacy
Divisions: Proceeding
Depositing User: F.X. Hadi
Date Deposited: 27 Nov 2019 03:37
Last Modified: 05 Dec 2019 02:01
URI: http://repository.wima.ac.id/id/eprint/20195

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