Metal-Organic framework as a drug carrier of furosemide

Devi, Yanita and Ang, Ignatius (2019) Metal-Organic framework as a drug carrier of furosemide. Working Paper (Laporan Penelitian Laboratorium). Faculty of Engineering, Surabaya. (Unpublished)

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Abstract

Recently, pharmaceutical industries have developed more than 40% NCE (New Chemical Entities) to satisfy the needs of rapid treatment toward various diseases. Nevertheless, majority of those developments have several problems for instance low solubility and/or low permeability thus a suitable delivery system is required. Furosemide is a loop diuretic drug with those several problems. To the best of our knowledge, utilizing nanoparticle with tunable porosity such as Metal-Organic Framework (MOF) as drug delivery of Furosemide has yet to be found. Synthesis of Metal-Organic Framework (MOF) known as MIL-100(Fe) was conducted via non-solvothermal method at room temperature under stirring condition using FeSO4.7H2O, H3BTC, and NaOH as the raw materials. Several experiments were conducted to observe the synthesis, loading, and release behaviors of Furosemide using MIL-100(Fe) as drug carrier. From the results obtained, the optimum molar ratio of NaOH added in the synthesis of MIL-100(Fe) was found to be X=3. The effect of adsorbent dose exhibits a decrease number in the value of qe and qt as the mass of adsorbent increases, vice versa. The adsorption kinetic could be represented by the pseudo-first-order model, while the adsorption isotherm fitted well with Langmuir isotherm model. The release of Furosemide from MIL-100(Fe) in PBS at pH 5.8 and 7.4 fitted well with the first-order kinetic and Korsmeyer-Peppas model, respectively, which demonstrated a sustainable release of the drug.

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