Hydrothermal synthesize of HF-Free MIL-100(Fe) for isoniazid-drug delivery

Simon, Meta A and Anggraeni, Erlina and Soetaredjo, Felycia Edi and Santoso, Shella Permatasari and Irawaty, Wenny and Thanh, Truong Chi and Hartono, Sandy Budi and Yuliana, Maria and Ismadji, Suryadi (2019) Hydrothermal synthesize of HF-Free MIL-100(Fe) for isoniazid-drug delivery. Hydrothermal synthesize of HF-Free MIL-100(Fe) for isoniazid-drug delivery, 9. pp. 1-11. ISSN 20452322

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Official URL: https://www.nature.com/articles/s41598-019-53436-3


Sustainable development of drug delivery materials with good biocompatibility and controlled-release is a popular topic among researchers. In this research study, we demonstrated the potential of the metal-organic framework, that is MIL-100(Fe), as a drug delivery platform for isoniazid (INH). The MIL-100(Fe) was prepared by using the hydroluoric acid-free hydrothermal method. Several physical measurements were conducted to characterize the MIL-100(Fe), including x-ray difraction (XRD), scanning electron microscopy (SEM), nitrogen sorption, and thermal-gravimetric (TG). The synthesized MIL-100(Fe) has octahedron-shaped particles with superior properties, that is large surface area (1456.10 m2/g) and pore volume (1.25 cm3/g). The drug loading rate and capacity were determined by means of adsorption kinetic and isotherm. The studied INH@MIL-100(Fe) adsorption system kinetics follow the pseudo-irst-order model, while the isotherm system follows the Langmuir model with the maximum adsorption capacity of 128.5 mg/g at 30 °C. MIL-100(Fe) shows adequate biocompatibility, also exhibits a reasonable and controlled drug release kinetics. The results obtained show that MIL-100(Fe) can be a good choice of drug delivery platform among other available platforms.

Item Type: Article
Subjects: Engineering > Chemical Engineering
Divisions: Faculty of Engineering > Chemical Engineering Study Program
Depositing User: Wenny Irawaty
Date Deposited: 07 Feb 2020 10:04
Last Modified: 21 Jul 2020 05:49
URI: http://repository.wima.ac.id/id/eprint/21506

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