Hartono, Sandy Budi, Hadisoewignyo, Lannie, Irawaty, Wenny, Trisna, Luciana and Wijaya, Robby (2018) Porous silica nanoparticles as carrier for curcumin delivery. In: AIP Conference Proceedings 020007 (2018), April 2018, Surabaya.
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Abstract
Mesoporous silica nanoparticles (MSN) with large surface areas and pore volumes show great potential as drug and gene carriers. However, there are still some challenging issues hinders their clinical application. Many types of research in the use of mesoporous silica material for drug and gene delivery involving complex and rigorous procedures. A facile and reproducible procedure to prepare combined drug carrier is required. We investigated the effect of physiochemical parameters of mesoporous silica, including structural symmetry (cubic and hexagonal), particles size (micro size: 1-2 μm and nano size: 100 -300 nm), on the solubility and release profile of curcumin. Transmission Electron Microscopy, XRay Powder Diffraction, and Nitrogen sorption were used to confirm the synthesis of the mesoporous silica materials. Mesoporous silica materials with different mesostructures and size have been synthesized successfully. Curcumin has anti-oxidant, anti-inflammation and antivirus properties which are beneficial to fight various diseases such as diabetic, cancer, allergic, arthritis and Alzheimer. Curcumin has low solubility which minimizes its therapeutic effect. The use of nanoporous material to carry and release the loaded molecules is expected to enhance curcumin solubility. Mesoporous silica materials with a cubic mesostructure had a higher release profile and curcumin solubility, while mesoporous silica materials with a particle size in the range of nano meter (100-300) nm also show better release profile and solubility.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Additional Information: | Prosiding Seminar Internasional Terindexs Scopus Vol. 1945, No. 1, 3 April 2018, ISBN: 978-0-7354-1640-6 |
| Subjects: | Pharmacy |
| Divisions: | Proceeding |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 20 Jan 2021 05:38 |
| Last Modified: | 07 Feb 2022 08:25 |
| URI: | http://repository.ukwms.ac.id/id/eprint/24163 |
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