Pengaruh ibuprofen dan kombinasi parasetamolibuprofen terhadap tukak lambung secara makroskopis dan mikroskopis pada tikus (Rattus Norvegicus)

Anestesya S.J Bisinglasi, . (2015) Pengaruh ibuprofen dan kombinasi parasetamolibuprofen terhadap tukak lambung secara makroskopis dan mikroskopis pada tikus (Rattus Norvegicus). Undergraduate thesis, Widya Mandala Catholic University Surabaya.

[img]
Preview
Text (ABSTRAK)
Abstrak.pdf

Download (4MB) | Preview
[img]
Preview
Text (BAB 1)
Bab 1.pdf

Download (54kB) | Preview
[img] Text (BAB 2)
Bab 2.pdf
Restricted to Registered users only

Download (467kB)
[img] Text (BAB 3)
Bab 3.pdf
Restricted to Registered users only

Download (100kB)
[img] Text (BAB 4)
Bab 4.pdf
Restricted to Registered users only

Download (635kB)
[img]
Preview
Text (BAB 5)
Bab 5.pdf

Download (63kB) | Preview
[img] Text (LAMPIRAN)
Lampiran.pdf
Restricted to Registered users only

Download (412kB)

Abstract

Ibuprofen is a propionic acid phenyl derivatives have is an anti inflammatory, analgesic and antipiretic agent. Ibuprofen is often used to use repeatedly in a day and if the use of excessive doses over a long period can cause gastrointestinal disturbances. This study was aimed to determine whether there are differences in picture comparisons between the macroscopic and microscopic gastric administration of ibuprofen and paracetamol-ibuprofen combination. This study is an experimental research using Post Test Randomized Controlled Group Design. As much as 18 male wistar rats, were used and divided into 3 groups of eighteen : control group, group of ibuprofen 200mg/kgBW and group of Paracetamol-Ibuprofen 350- 200mg/kgBW orally for 7 days. Then , on the 8th days, the rats were sacrificied by cervical dislocation and gastric organ were taken for observation macroscopic and microscopic with hematoxylin eosin staining. The obtained data were analyzed by Kruskal Wallis test followed by Mann Whitney, with the significant. The results showed that the number of ulcer index of control group is 2.00, ibuprofen is 8.16 and Paracetamol-Ibuprofen is 7.00. The study concluded that the effect of a combination of paracetamol-ibuprofen reducing peptic ulcers of macroscopic and microscopic in rats lower than ibuprofen.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Ibuprofen, peptic ulcer, rats
Subjects: Pharmacy > Pharmacist Professional
Pharmacy
Divisions: Faculty of Pharmacy > Pharmacy Study Program
Depositing User: Thomas Aryanatan Lena
Date Deposited: 25 Jan 2016 03:43
Last Modified: 13 Mar 2017 04:54
URI: http://repository.wima.ac.id/id/eprint/5053

Actions (login required)

View Item View Item