Pengaruh ekstrak air herba sambiloto (andrographis paniculata) dan daun salam (syzygium polyanthum) terhadap jumlah tnf-α, makrofag dan neutrofil pada tikus yang diinduksi aloksan

Septiana, Silvia (2015) Pengaruh ekstrak air herba sambiloto (andrographis paniculata) dan daun salam (syzygium polyanthum) terhadap jumlah tnf-α, makrofag dan neutrofil pada tikus yang diinduksi aloksan. Undergraduate thesis, Widya Mandala Catholic University Surabaya.

[img]
Preview
Text (ABSTRAK)
Abstrak.pdf

Download (399kB) | Preview
[img]
Preview
Text (BAB 1)
Bab 1.pdf

Download (231kB) | Preview
[img] Text (BAB 2)
Bab 2.pdf
Restricted to Registered users only

Download (468kB)
[img] Text (BAB 3)
Bab 3.pdf
Restricted to Registered users only

Download (273kB)
[img] Text (BAB 4)
Bab 4.pdf
Restricted to Registered users only

Download (367kB)
[img]
Preview
Text (BAB 5)
Bab 5.pdf

Download (301kB) | Preview
[img] Text (LAMPIRAN)
Lampiran.pdf
Restricted to Registered users only

Download (663kB)

Abstract

Sambiloto (Andrographis paniculata) herbs and Salam (Syzygium polyanthum) leaves are plants used in traditional medicine. Various studies were conducted on that plants, one of them is antidiabetic potential. The presence of accumulated excess fat was regarded as foreign bodies caused system imun in our body produced cytokines. Cytokines triggers an inflammatory reaction caused inflammatory mediators being produced, for example macrophages, neutrophils and TNF-α respectively. This study aimed to determine the effect of water extract Sambiloto herbs and water extract of Salam leaves on their potential to decreased the number of TNF-α, macrophages, and neutrophils in diabetic male wistar rats. Experimental animals were divided into 5 groups with 3 rats in each groups. The group were normal control CMC-Na 0,5%, alloxan-induced negative control, group of treatment which induced by alloxan and treated metformin with dosage 63 mg/kg BB as positive control, group of treatment which induced by alloxan and treated with water extract of Sambiloto herbs at a dose of 200 mg/kg BB as Sambiloto group and group of treatment which induced by alloxan and treated with water extract of Salam leaves with a dose of 200 mg/ml as Salam group. The results were analyzed by oneway ANOVA, followed by Post Hoc Tukey. The result of the analysis showed water extract of Sambiloto herbs (Andrographis paniculata) and water extract of Salam leaves (Syzygium polyanthum) reduced the amount of macrophages, neutrophils and TNF-α in diabetic male wistar rats. Water extract of Sambiloto herbs can reduce the number of macrophages by 30,23 % and water extract of Salam leaves can reduce the number of macrophages by 29,81 %. Water extract of Sambiloto herbs can reduce the number of neutrophils by 40,77 % and water extract of Salam leaves can reduce the number of neutrophils by 41,54 %. Water extract of Sambiloto herbs can reduce the number of TNF-α by 81,54 % and water extract of Salam leaves can reduce the number of TNF-α by 74,10 %.

Item Type: Thesis (Undergraduate)
Department: ["eprint_fieldopt_department_Faculty of Pharmacy" not defined]
Uncontrolled Keywords: Andrographis paniculata, Syzygium polyanthum, makrofag, neutrofil, TNF-α.
Subjects: Pharmacy > Pharmacist Professional
Pharmacy
Divisions: Faculty of Pharmacy
Depositing User: Thomas Aryanatan Lena
Date Deposited: 25 Jan 2016 06:46
Last Modified: 25 Jan 2016 06:46
URI: http://repository.wima.ac.id/id/eprint/5081

Actions (login required)

View Item View Item