Formulation of enteric coated tablets containing pineapple (Ananas cqmosus Merr.) fruit juice

Widodo, Teguh, Alisyahbana, , and Irawan, Ferry (2012) Formulation of enteric coated tablets containing pineapple (Ananas cqmosus Merr.) fruit juice. In: Proceedings of international conference on medicinat plants. Universitas Jenderal Soedirman, Purwokerto, pp. 177-183. ISBN 978-979-9204-80-6 (Unpublished)

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Abstract

Pineapple fruit has been empirically used as an anthelmintic. one obstacle of the usage of pineapple as an anthelmintic its is that chemical content can increase the incidence of gastric mucous membrane irritation. To overcome this problem, an enteric coated tablet dosage from was selected, which can prevent the dissolution of tablet in the gastric fluid but it can dissolve in an alkaline medium. Thus it can eradicate the worms that live in the intestine. A study on the formulation of enteric coated tablet containing pineapple fruit juice has been carried out. Pineapple juice was obtained by using a juicer. Tablet were prepared by wet granulation method.The physical quality of resulting granules was evaluated including moisture content. repose angle, flow rate and compressibility. Granules were then compressed to yield rablets of 300 mg, in which each tablet contains 71.5 mg of pineapple fruit extract. The quality of resulting tablets was evaluated including friability. Hardness, weight uniformities and disintegration time. One formula of tablet was prepared and then coated using a coating solution of Eudragit L-100 with the additional weights of 3%, 4%, and 5% The quality of resulting enteric coated tablets was evaluated including additional weight, uniformities, hardness, disintegration time, and physical-appearance of tablet. The stability testing of contents was performed using TLC. It can be concluded that pineapple fruit juice could be formulated as an enteric coated tablet with the additional weight of 4%

Item Type: Book Section
Uncontrolled Keywords: Coated tablet: eudragit L-1 00: pineapple fruit
Subjects: Pharmacy
Divisions: Proceeding > Faculty of Pharmacy
Depositing User: stefanus redhitya
Date Deposited: 03 Apr 2018 08:15
Last Modified: 02 Oct 2018 04:54
URI: http://repository.wima.ac.id/id/eprint/14466

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