Antioxidant, Anti-Inflammatory, Cytotoxicity and Cytoprotection Activities of Crassocephalum Crepidioides (Benth.) S. Moore. Extracts and Its Phytochemical Composition

Wijaya, Sumi, Nee, Ting Kang, Jin, Khoo Teng, Din, Wardah Mustafa and Wiart, Christophe (2011) Antioxidant, Anti-Inflammatory, Cytotoxicity and Cytoprotection Activities of Crassocephalum Crepidioides (Benth.) S. Moore. Extracts and Its Phytochemical Composition. European Journal of Scientific Research, 67 (1). pp. 1-10. ISSN 1450-216X, Journal Internasional Terindek di SJR

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Abstract

The hexane, ethyl acetate, ethanol and water extracts of Crassocephalum crepidioides (Benth.) S. Moore. were assessed for their antioxidant, anti-inflammatory, cytoxicity and cytoprotective activities. The ethanol extract displayed profound antioxidant activities and inhibited the enzymatic activity of 5-lipoxygenase (5-LOX). The ethanol extract of Crassocephalum crepidioides (Benth.) S. Moore. at a concentration of 100 μg/ml, was non-toxic against MRC-5 and HepG2 cell lines. At the concentration of 25 μg/ml it gave a percentage of cytoprotection with the value of 69.47%. Phytochemical analysis of the ethanol extract revealed the presence of phenols and flavonoids with 422.22 gallic acid equivalent (mg/g) and 3.46 quercetin equivalent (mg/g). Phenolic compounds and flavonoids impart to Crassocephalum crepidioides (Benth.) S. Moore. its biological properties.

Item Type: Article
Uncontrolled Keywords: --
Subjects: Pharmacy
Divisions: Journal Publication
Depositing User: F.X. Hadi
Date Deposited: 09 Oct 2019 07:32
Last Modified: 16 Aug 2021 02:58
URI: http://repository.wima.ac.id/id/eprint/20125

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