Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system

Hadisoewignyo, Lannie, Hartono, Sandy Budi, Kresnamurti, Angelica, Soeliono, Ivonne, Nataline, Yolenta, Prakoso, Gilang Ardi and Aulia, Daeng Agus Rizka Elok (2018) Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system. Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system, 9 (9). pp. 1-9. ISSN 20436262

[thumbnail of Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system]
Preview
Text (Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system)
5-Evaluation_of_anti-inflammatory_.pdf

Download (1MB) | Preview
[thumbnail of Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system_peer_review_] Text (Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system_peer_review_)
4-R1&2-Evaluation_of_anti-inflammatory_.pdf

Download (1MB)
[thumbnail of Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system]
Preview
Text (Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system)
5-Evaluation_of_anti-inflammatory_Hasil Cek Similarity.pdf

Download (3MB) | Preview
[thumbnail of Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system_koresponden_] Text (Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system_koresponden_)
4-Evaluation_of_anti-inflammatory_.pdf

Download (256kB)

Abstract

Curcumin, well-known polyphenol drug shows great promise as a therapeutic agent. However, a major concern for this molecule is its low bioavailability. We have recently reported the use of mesoporous silica nanoparticles (MSN) to enhance curcumin bioavailability significantly. In the present work, we investigated anti-inflammatory effects of the curcumin-MSN and related side effects caused to the gastrointestinal tract and kidney, compared with curcumin and diclofenac sodium. The anti-inflammatory effect tests were performed by induction of carrageenan in Wistar rat feet. Ulcerogenic observations were performed macroscopically and microscopically. Kidney histopathology were performed on the average number of necrotic cells of the proximal tubule and distal tubules. There was anti-inflammatory activity in the administration of peroral curcumin and curcumin-MSN, in the absence of significant macroscopic and microscopic changes in the stomach organ. Curcumin-MSN showed a high anti-inflammatory activity comparable to diclofenac sodium but with a significantly enhanced biocompatibility.

Item Type: Article
Uncontrolled Keywords: curcumin, mesoporous silica nanoparticles (MSN), non-steroidal anti-inflammatory drugs, anti-inflammatory effects, kidney histopathology
Subjects: Pharmacy
Divisions: Journal Publication
Depositing User: F.X. Hadi
Date Deposited: 19 Jan 2021 07:07
Last Modified: 08 May 2023 04:13
URI: http://repository.ukwms.ac.id/id/eprint/24099

Actions (login required)

View Item View Item