Optimization Formula of Aloe Vera L.Powder Extract Effervescent Granules

Hidayat, Yuliana and Hadisoewignyo, Lannie (2010) Optimization Formula of Aloe Vera L.Powder Extract Effervescent Granules. In: Proceedings of International Conference on Medicinal Plants-Surabaya, 21 Juli 2010, Surabaya, ISBN: 978-602-96839-1-2, 978-602-96839-3-6.

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Abstract

Aloe vera L. is one of medicinal plants spread throughout Indonesia. Based on researches and experiences empirically, Aloe vera L. has been proven to cure or prevent some diseases. The aims of this research were to make effervescent granules of Aloe vera L. powder extract and looking for optimum formula of effervescent granules of Aloe vera L. powder extract which have granules and dissolving time physical properties which are appropriate with rule and regulations. Optimization techniques used this research was factorial design method with two factors and two levels which are concentration of PVP K-30 with low level 2Vo andhighlevel SVo, and concentration of lactose monohydrate with low level 5Vo and high level ll%o. The observed responses to determine the optimum granules formula in factorial design are angle of repose, granules friability, and dissolving time. The result showed that PVP K-30, lactose monohydrate, ind interaction between PVP K-30 and lactose monohydrate significantly influenced the angle of repose, granules friability, and dissolving time. Based on the Design-Expert optimization program, effervescent granules formula with optimum physical properties of gtanules to reach for 4.58Vo of PVP K-30 and9.O8Vo of lactose monohydrate and the result is angle of repose 36.42', granules friability 0.93Vo, and granules dissolving time 1.76 minutes.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Aloe vera L., PVP K-30, lactose monohydrate, effervescent granules, factorial design
Subjects: Pharmacy
Divisions: Proceeding > Faculty of Pharmacy
Depositing User: F.X. Hadi
Date Deposited: 20 Jan 2021 07:51
Last Modified: 14 Apr 2021 08:02
URI: http://repository.wima.ac.id/id/eprint/24194

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