Antioxidant Activity of Extracts and Fractions of Sambiloto Herbs and Salam Leaves

Hadisoewignyo, Lannie, Ervina, Martha, Soegianto, Lisa and Kurniawan, Hendra (2012) Antioxidant Activity of Extracts and Fractions of Sambiloto Herbs and Salam Leaves. In: Proceedings of International Conference on Medicinal Plants-Surabaya, 21 Juli 2010, Surabaya, ISBN: 978-602-96839-1-2, 978-602-96839-3-6.

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Abstract

Antioxidants <ire subslance ll'hich able lo scavenge li-ee radiu1ls. Sambiloto herbs (Andrngraphis prn1iculata Nees) a11CI sc lrnn leaves (Syzygium polyanlhum) extracts have potential or antioxidant activity. so the cornbim1tion is expeclcd not only reduce blood sugar levels. bul also pn:vcnl IL1rthe1· co111pliu1tions of chronic diseases. In the case of chronk hypcrgi)'Cemia will increase oxidative stress which is resulting in a reduced 11u111ber oi'glucose transportc1·s. This rneclrn11ism \\'ill increase insulin resistance, lack oJ' i11sulin sig11aling ancl impair i11suli11 sccretio11 by pancreatic fl cells. The aims of this resea1·ch was to delermine antioxida11t aclivity ol'extracts a11d Ji·actio11s orsambiloto herbs a11d salam le<wes. As a screen by TLC autograph)' method 01· exlracts and rnictions \\'ere show11 llrnl aqueous Ji·<iction or lhe leaves and herbs clhanol exlracl ol' sambilolo and salam have slro11gesl scavenger capacily or Dl'l'J-1 on RI' 0.58: 0.73 and 0.84 tor sambilolo aqueous frnclio11: \\'h ile sal<1m aqueous lh1ction on IU 0.2 1: 0.34: 0.40: 0.44 and qucrcclin <lS anlioxida11t rclcrencc on Rf 0.86. Qu<111lil:1livc anlioxidanl capacity or aqueous li·ac1ion ol' lhe e.,lracts were assessed b) inhibition or DPPl I ( 1. 1-diphenyl-2-picryl-h)dl"<lzyl) Ii-cc rndical scavenging metlwd which assay by speclrophotnmctry <1t ll'<Jvclenght 515 nm. Antioxidant c:1paci1y or lhe fr<1c1ions was showed by IC5,,. As rcsull ll'as measured lhal I C,11 s<1mbi loin herbs aqueous fraction \\'<IS 46. 15 pg/m 1.: 11 h ilc I C50 sal<Jlll leaves <1qucous li·:1clinn \\'as 18 .74 pg/ ml .. These rcsulls W<1s suggcslcd lhal lhc anlio.'\idanl capacity or uqucous li·aclion nl' sambiloto hed1s <mcl s<ilam le:1vcs hi gher llrn11 ils exln1cls and il mighl be have lhcrapeutic vulue in prcvenl adva11ccd CO lllJJlic<1lio11 in clmrnic dise<1ses.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: onls: s<11nbilolo lm·bs. salun1 lcm·es. <111lioxicln11l c<1pacily. l)J>l'H
Subjects: Pharmacy
Divisions: Proceeding
Depositing User: F.X. Hadi
Date Deposited: 29 Jan 2021 07:08
Last Modified: 29 Jan 2021 07:08
URI: http://repository.wima.ac.id/id/eprint/25029

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