Tamayanti, Wahyu Dewi, Kristanti, Lidwina Tri, Kurniawan, Hendra, Hadisoewignyo, Lannie, Soegianto, Lisa and Widharna, Ratna Megawati (2013) Water Fraction of Sambiloto (Andrographis Paniculata Nees) Ethanol Extract Efficacy in Inducing the Number of Macrophage, Neutrophil, and The Level of TNF-@ on Wistar Rats. In: Proceeding International Conference on Central Management of Central Cytotoxic Reconstitution, 25 Mei 2013, Yogyakarta, ISBN: 978-979-18458-6-1.
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Abstract
Background. The study of the effect of water Ji-action ofSambiloto (Andrographis paniculata Nees) ethanol extract on the number of macrophage, neutrophil, and level of TNF-a in the body fluid of male Wistar rats after Staphylococcus aureus induction. Methods. Animals were divided into 3 groups, namely: negative control (NC), treatment (T), and positive control (PC) group. The NC, T and PC groups were administered by 0.9% NaCl, water Ji-action ofSambiloto ethanol extract of40mg/200g BW dose, and ibuprofen of 7.2 mg/200g BW dose, respectively. The treatment was performed for 7 consecutive days. The number of macrophages, neutrophils, was identified using light microscope whereas the TNF-a level was identified using ELISA. Outcome Measured. The number of macrophage, neutrophil, and level of TNF-a in the body fluid of male Wis tar rats after Staphylococcus au re us induction. Results. The number of macrophages in the KC, the T, and the PC groups were 2.33 ± 1.58; 3.80 ± 4.06; and 2.67±1.55 cells, respectively. The number ofneutrophils were 0.83 ± 0.33; 0.58 ± 0.32; and 1.33 ± 0.38 cells respective to the KN, T, and PC groups. The level ofTNF-a were 17. 78 ± 11.67; 23.48 ± 15.95; and 27.90 ± 30.54 pg/ml respective to the KN, the T, and PC groups. Conclusion. This study indicated that water Ji-action of Sambiloto ethanol extract able to increase the number of macrophage and TNF-a level yet decrease the number of neutrophil in the body fluids of male Wis tar rats after Staphylococcus aitreus induction.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | macrophages, neutrophils, TNF-a, Herba Sambiloto, ibuprofen |
| Subjects: | Pharmacy |
| Divisions: | Proceeding |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 29 Jan 2021 07:21 |
| Last Modified: | 07 Feb 2022 08:41 |
| URI: | http://repository.ukwms.ac.id/id/eprint/25030 |
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