Oftimizing Combination of Sambiloto Herbal Water Fraction and Salam Leaf Water Fration As Anti-Inflammation

Mustafa, Raymond Harris, Hadisoewignyo, Lannie, Ervina, Martha, Soegianto, Lisa and Tamayanti, Wahyu Dewi (2015) Oftimizing Combination of Sambiloto Herbal Water Fraction and Salam Leaf Water Fration As Anti-Inflammation. In: Proceeding International Conference “Current Breakthrough in Pharmacy Materials and Analyses”, Surakarta, ISBN: 9-772476-969006.

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Abstract

Sambiloto herbs (Andrographis panicu/ata Nees) and salam leaves (Syzygium polyanthum), which are effective to reduce blood sugar level with different mechanism, have been suggested to produce a synergy as antioxidant and anti-inflammatory agent, hence the optimum combination formula is remained to be elaborated. By reducing blood sugar level and showing antioxidant, and anti-inflammatory activity, both plants were hypothesized of its ability ameliorating diabetes mellitus complexicity. This study aimed to discover the optimal combination formula sambiloto herbs (Andrograpl1is paniculata Nees) and salam leaves (Syzygium polyantlmm) water fraction to produce anti-inflammation effect. Carrageenan was used to induced the inflammatory condition. Optimization was conducted by factorial design utilising 2 factors and 2 levels. Both factors, sambiloto herbs (Andrographis paniculata Nees) and salam leaves (Syzygium polyanthum) in the range of low level 1:10 and high level 10:1 with the used doses were 100 mg/kg BW at low level and 300 mg/kg BW for high level. The observed parameters were anti inflammation potential percent and edema rate. Conclusively, this study proposed that optimum combination formula ofsambiloto herbal: salam leaves water fraction = 1.14 : 9.87 with 234 mg dose. The combination formula was theoretically resulted the optimum anti inflammation potential percent of 45.68%, and ER of 38.39% compared with other combination formulas.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: salam leaf; sambiloto herbal; fraction; anti inflammation; factorial design water
Subjects: Pharmacy
Divisions: Proceeding
Depositing User: F.X. Hadi
Date Deposited: 29 Jan 2021 07:38
Last Modified: 29 Jan 2021 07:38
URI: http://repository.wima.ac.id/id/eprint/25033

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