Optimasi Formula Tablet Lepas Lambat Ibuprofen

Apriyadi, Fransiskus, Hadisoewignyo, Lannie and Hermanu, Liliek (2011) Optimasi Formula Tablet Lepas Lambat Ibuprofen. Optimasi Formula Tablet Lepas Lambat Ibuprofen, 5 (4). pp. 195-204. ISSN 1412-1107, Jurnal Nasional Terakreditasi Sesuai SK Dirjen Dikti No. 83/DIKTl/ Kep/2009 Tgl. 6 Juli 2009

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Abstract

Ibuprofen was one type of antiinflammation drug that is often used so frequently in a day. Therefore, ibuprofen should be formulated in the form of sustained release tablet and find the optimum fonnula using factorial design. Factors used are a concentration of combination locust bean gum - xanthan gum matrix at 5% - 10% and concentration PVP K-30 at 3% - 5%. Preferred response Banakar follow the criteria was percent of dissolved drug in 3 hours at 25% - 50% and the percent of dissolved drug in 6 hours at 45% - 75%. The purpose of this study was to determine the effect of both factors and their interactions and get the optimum formula for the disposal of the following criteria Banakar. Concentration of combination xanthan gum-locust bean gum and concentration of PVP K-30 factor inhibit dissolved ibuprofen from tablets. While their interaction increase dissolved ibuprofen from tablet. Based on Design-Expert program optimation, optimum formula was obtained using a concentration of combination locust bean gum - xanthan gum matrix 7.58% and concentration of PVP K-30 3.09% would be result dissolved drug in 3 hours amounted to 49.3137% and dissolved drug in 6 hours amounted to 51.7607%.

Item Type: Article
Uncontrolled Keywords: ibuprofen, xanthan gum, locust bean gum, PVP K-30
Subjects: Pharmacy
Divisions: Journal Publication
Depositing User: F.X. Hadi
Date Deposited: 10 May 2021 08:03
Last Modified: 07 Feb 2022 07:33
URI: http://repository.wima.ac.id/id/eprint/25600

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