An iron-carboxylate-based metal-organic framework for furosemide loading and release

Devi, Yanita, Ang, Ignatius, Soetaredjo, Felycia Edi, Santoso, Shella Permatasari, Irawaty, Wenny, Yuliana, Maria, Angkawijaya, Artik Elisa, Hartono, Sandy Budi, Tran-Nguyen, Phuong Lan, Ismadji, Suryadi and Ju, Yi-Hsu (2020) An iron-carboxylate-based metal-organic framework for furosemide loading and release. Journal of Materials Science, 55 (28). pp. 13785-13798. ISSN 0022-2461

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An iron-carboxylate-based metal-organic framework, Fe-MIL100, has been synthesized using acid-free solvent at room temperature. Fe-MIL100 was prepared by combining Fe/H3BTC/NaOH/H2O (H3BTC = trimesic acid) at a molar ratio of 1.5:1.0:x:880, where x is the varied NaOH concentration at 1.5, 3.0, and 5.0 M. The effect of NaOH molar concentration on the formation of Fe- MIL100 was studied. Characterizations of the Fe-MIL100 were carried out using powder X-ray diffraction (XRD), scanning electron microscopy (SEM), nitrogen (N2) adsorption-desorption, and thermogravimetry analysis (TGA). The obtained Fe-MIL100, with x NaOH of 3.0 M, has an octahedral crystal shape (a = 73.41 A˚), crystal size ranging from 100 to 400 nm, BET surface area of 1,446.4 m2/g, a pore volume of 0.829 cm3/g, and thermal degradation temperature of 358C. The potential of Fe-MIL100, a drug carrier device, was tested against Furosemide (a loop diuretic). As studied using the Langmuir adsorption isotherm model, 392.4 mg of Furosemide can be loaded per g of Fe-MIL100. The kinetic release of Furosemide was examined at 2 different biological pH of 5.8 and 7.4. The release profile of Furosemide was recorded within 24 h; it was found that the release profile follows the pseudo-first-order kinetics at pH 5.8 with a percent cumulative release of 41.56% and Korsmeyer-Peppas model at pH 7.4 with a percent cumulative release of 68.46%. The electrostatic repulsion drove the release of Furosemide from Fe-MIL100 due to the same negative charge of the compounds. Fe-MIL 100 at low concentration (< 30 g/mL) shows good biocompatibility toward the 7F2 normal cell lines.

Item Type: Article
Subjects: Engineering > Chemical Engineering
Divisions: Faculty of Engineering > Chemical Engineering Study Program
Depositing User: Wenny Irawaty
Date Deposited: 14 Aug 2021 03:01
Last Modified: 02 Apr 2022 05:23

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