Multifunctional large pore mesoporous silica nanoparticles as a novel gene carrier

Hartono, Sandy Budi, Wenyi, Gu, Meihua, Yu, Jie, Yang, Strouninan, Ekaterina, Gao, Qing Lu, Shi, Zhang Qiao and Chengzhong, Yu (2012) Multifunctional large pore mesoporous silica nanoparticles as a novel gene carrier. In: International Conference on Nanotechnology in Medicine, 7-9 November, London, United Kingdom.

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Small interfering RNA (siRNA) based therapeutics for cancer treatments have gained considerable attention due to the high potency of siRNA in suppressing pathogenic gene expression [1]. Yet, there are drawbacks that limit siRNA application in vivo: the vulnerability of siRNA against nucleases and the inability of the nucleic acids molecules to diffuse across the cellular membranes. Nanovectors hold great promise for overcoming these limitations towards the development of efficient siRNA therapy. Various nanovectors such as lipids, polymers and inorganic nano-particles have been extensively studied. Among these nanovectors, mesoporous silica nanoparticles (MSN) show promising potential as the next-generation gene delivery carriers.

Item Type: Conference or Workshop Item (Paper)
Subjects: Engineering > Chemical Engineering
Divisions: Proceeding > Faculty of Engineering
Depositing User: Sandy Budi Hartono
Date Deposited: 21 Jan 2016 09:44
Last Modified: 23 May 2017 05:24

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